HAPILA - innovation and experience

<body> <font face="Verdana" size="1"> Synthesis, Purification and Finishing of Active Pharmaceutical Ingredients (API)<br> <a href="http://www.hapila.de/index_en.html" target="_parent">HAPILA GmbH</a> has been established as a specialist provider of sophisticated services in the field of pharmaceutical and chemical development for active pharmaceutical ingredients. It offers customers from the Pharma and Biotech sectors complete solutions for <a href="http://www.hapila.de/frames/reference_en.html">chemical and process engineering issues</a>. including <a href="http://www.hapila.de/frames/regulatory_en.html">analytics, documentation as well as consultancy</a>. Our know-how covers the development of <a href="http://www.hapila.de/frames/chemdev_en.html">chemical syntheses</a>, <a href="http://www.hapila.de/frames/purification_en.html">purification processes</a> and <a href="http://www.hapila.de/frames/particledesign_en.html"> technologies for physical conditioning</a> of APIs. <br><br> <b><a href="http://www.hapila.de/frames/chemdev_en.html">Achievements chemical development</a></b><br> <ul> <LI>Development and optimization of syntheses for APIs and intermediates <LI>Preparation of feasibility studies based on thorough literature and patent research <LI>Dealing with high-active substances and reactions with high risk potential <LI>Isolation, characterization and synthesis of impurities and degradation products <LI>Application of advanced technologies like micro and photo reactor systems <LI>Development and optimization of processes for purification of substances and separation of mixtures <LI>Process optimization and validation </ul> <br> <b><a href="http://www.hapila.de/frames/particledesign_en.html">Applications for final finishing</a></b><br> <ul> <LI>Development of processes to provide ultrapure APIs <LI>Specifically designed particle development according to requirements for dosage, release and stability <LI>Selection of the optimal polymorphic design <LI>APIs and compounds for pulmonary application with specific particle size distributions <LI>Micro particles of difficult-to-micronize APIs <LI>Compounds of active substances and special auxiliaries for dissolution and permeation enhancement <LI>Analytics of polymorphism, crystallinity and polymorphic purity <LI>Analytics of nano and micro particle systems </ul> <br> </font> </body>